2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-106635
    Suriclone 53813-83-5
    Suriclone (RP31264) is a GABA receptor agonist. Suriclone is an anxiolytic agent with a high affinity for the benzodiazepine receptors. Suriclone has oral activity.
    Suriclone
  • HY-106645
    Cloxacepride 65569-29-1
    Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity.
    Cloxacepride
  • HY-106659
    SCH 900978 873947-10-5
    SCH 900978 (NK-1 Antagonist 1) is an antagonist of NK-1 receptor, used in the research of NK-1 related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression.
    SCH 900978
  • HY-106660
    BP 897 hydrochloride 314776-92-6 99.84%
    BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM).
    BP 897 hydrochloride
  • HY-106670
    Dulozafone 75616-02-3
    Dulozafone (F1933) shows anticonvulsant activity and can be used for epilepsy research.
    Dulozafone
  • HY-106716
    SR 41378 93181-85-2
    SR 41378 is an orally active aminopyrazine derivative. SR 41378 has anticonvulsant, antianxiety and hypnotic activities.
    SR 41378
  • HY-106732
    AT-076 1657028-64-2
    AT-076 is an opioid pan antagonist at nociception, kappa, mu, and delta opioid receptors, with Ki values of 1.75 nM (NOP), 1.67 nM (MOP), 1.14 nM (KOP) and 19.6 nM (DOP), respectively.
    AT-076
  • HY-106736
    Etilefrine pivalate hydrochloride 42145-91-5
    Etilefrine pivalate hydrochloride is an orally active compound and can be used for study of migraine headaches.
    Etilefrine pivalate hydrochloride
  • HY-106741
    Bazinaprine 94011-82-2
    Bazinaprine (SR 95191), a derivative of Minaprine (HY-B0884), is an orally active inhibitor of type A monoamine oxidase (MAO). Bazinaprine can be used for research of depression.
    Bazinaprine
  • HY-106749
    E-0747 99599-78-7
    E-0747 is an antiarrhythmic drug that inhibits arrhythmias by inhibiting Na[+] channels in cardiomyocytes.
    E-0747
  • HY-106756
    Spiradoline 87151-85-7
    Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier.
    Spiradoline
  • HY-106769
    Fluparoxan 105182-45-4 99.66%
    Fluparoxan is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan is an anti-depressant agent.
    Fluparoxan
  • HY-106770
    Esuprone 91406-11-0
    Esuprone is a brain-penetrant, orally active and selective MAO A inhibitor with an IC50 of 7.3 nM. Esuprone can be used for neurological research.
    Esuprone
  • HY-10679A
    PF-03049423 402955-58-2
    PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke.
    PF-03049423
  • HY-106809
    BMY-21502 123259-91-6
    BMY-21502 (BMS-181168) is a pyrrolidinone derivative with memory- and cognition-enhancing activities. BMS-181168 attenuates hypoxia-induced deterioration in brain function, as delta/theta decreases, alpha activity increases and the centroid of the combined delta/theta waves is accelerated.
    BMY-21502
  • HY-106832
    Vatanidipine 116308-55-5
    Vatanidipine (Watanidipine) is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings.
    Vatanidipine
  • HY-106851
    Panadiplon 124423-84-3
    Panadiplon (FG 10571; PNU 78875), a benzodiazepine receptor, is a 5GABAA partial agonist. Panadiplon exhibits selectivity for 5GABAA receptors versus 1GABAA receptors.
    Panadiplon
  • HY-106860
    Gedocarnil 109623-97-4
    Gedocarnil is a compound used in research to explore central nervous system diseases and has potential anxiety-related activity. The use of gedocarnil provides an effective tool for further experimental research on anxiety. Gedocarnil may induce severe anxiety attacks in clinical trials.
    Gedocarnil
  • HY-106888
    CS-722 Free base 749179-13-3
    CS-722 Free base is a synthesized centrally acting muscle relaxant, and has a muscle relaxant activity and depressant effectson the spinal reflex. CS-722 Free base inhibits spontaneous inhibitory postsynaptic currents and excitatory postsynaptic currents in hippocampal cultures probably by an inhibition of both sodium and calcium currents.
    CS-722 Free base
  • HY-106916
    Unoprostone 120373-36-6 ≥99.0%
    Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.
    Unoprostone
Cat. No. Product Name / Synonyms Application Reactivity